Bratislava Medical Journal Vol.118, No.4, p.208-211, 2017

Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

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Bratislava Medical Journal Vol.118, No.4, p.208-211, 2017
Title: Protective effect of thymoquinone against cyclophosphamide-induced genotoxic damage in human lymphocytes
Author: S. Yuksel, S. Tasdemir, S. Korkmaz

Abstract: OBJECTIVE: Protective effect of thymoquinone (TQ) against the cytotoxic and genotoxic effects of cyclophosphamide (CP) was assessed in human peripheral blood lymphocyte culture. METHODS: Mitotic indices were determined as endpoints of cytotoxicity, while sister chromatid exchanges (SCE) served as endpoints of genotoxicity. Firstly, the genotoxic effect of 0.16 µg/ml of CP was tested and CP was detected as genotoxic. In the second set, CP group was treated with 20 µM and 40 µM TQ. RESULTS: TQ reduced the SCE frequencies, suggesting its protective action on human lymphocytes in vitro against the CP induced genotoxic damage. CONCLUSIONS: Our results suggest that TQ produces a protective mechanism against CP-induced genetic damage, and suggest a role of DNA strand breaks in the genotoxicity (Tab. 1, Fig. 1, Ref. 19).

Keywords: thymoquinone, cyclophosphamide, human lymphocytes, genotoxicity
	Published online: 02-May-2017
Year: 2017, Volume: 118, Issue: 4	Page From: 208, Page To: 211
doi:10.4149/BLL_2017_041
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