Home Neoplasma 2017 Neoplasma Vol.64, No.4, p.502-510, 2017

Journal info


6 times a year.
Founded: 1954
ISSN 0028-2685
ISSN 1338-4317 (online)

Published in English

Editorial Info
Abstracted and Indexed
Submission Guidelines

Select Journal







Webshop Cart

Your Cart is currently empty.

Info: Your browser does not accept cookies. To put products into your cart and purchase them you need to enable cookies.

Neoplasma Vol.64, No.4, p.502-510, 2017

Title: NFAT5 inhibits invasion and promotes apoptosis in hepatocellular carcinoma associated with osmolality
Author: X. Qin, Y. Wang, J. Li, Y. Xiao, Z. Liu

Abstract: Hepatocellular carcinoma (HCC) is one of the most difficult cancer disease for diagnosis and treatment, with a low survival rate and high recurrence rate and mortality. Nuclear factor of activated T-cells 5 (NFAT5) is mediated by osmolality and proved to be a carcinogenic gene in some tumor. However in our study we considered NFAT5 as tumor suppressor of HCC. RT-qPCR was performed for NFAT5 expression in tumor tissues. NaCl was applied to make hyperosmotic treatment. We knockdowned and overexpressed NFAT5 to investigate its role in HCC. FCM was used for apoptosis assay. Transwell and scratch assay is proceeded for invasion.
NFAT5 is downregulated in HCC tissue and cell lines, besides, upregulated by hyperosmolality. NFAT5 promotes apoptosis by regulating PARP-1,BAX/BCL2 while inhibits invasion through EMT-related protein claudin-1 and fibronectin. Hyperosmolality is also a protective factor for HCC. We considered hyperosmolality exhibited his protective effect by inducing NFAT5.
In a word, NFAT5 inhibits invasion and promotes apoptosis in HCC, associated with osmolality.

Keywords: NFAT5, HCC, hyperosmolality, invasion, apoptosis
Published online: 11-Jul-2017
Year: 2017, Volume: 64, Issue: 4 Page From: 502, Page To: 510
doi:10.4149/neo_2017_403


download file



© AEPress s.r.o
Copyright notice: For any permission to reproduce, archive or otherwise use the documents in the ELiS, please contact AEP.