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Bratislava Medical Journal Vol.118, No.5, p.273-277, 2017 |
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Title: Protective effect of pravastatin on doxorubicin-induced hepatotoxicity | ||
Author: E. Mansouri, A. Jangaran, A. Ashtari | ||
Abstract: OBJECTIVE: The present study was designed to investigate the possible protection of pravastatin against hepatic oxidative stress and dysfunctions induced by doxorubicin in rats. Doxorubicin caused a reduction in HDL and albumin levels (p < 0.01) as well as superoxide dismutase, glutathione peroxidase and catalase activities (p < 0.05) with a concomitant increase in liver malondialdehyde (p < 0.05) and liver damage (p < 0.001). Pravastatin reduced the scale liver injury (p < 0.001) and protected liver functions and other biochemical parameters (p < 0.01). Increase in malondialdehyde level associated with a reduction in antioxidant activities in the doxorubicin group was attenuated by pravastatin treatment (p < 0.05). |
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Keywords: doxorubicin, hepatotoxicity, pravastatin, oxidative stress | ||
Published online: 15-May-2017 | ||
Year: 2017, Volume: 118, Issue: 5 | Page From: 273, Page To: 277 | |
doi:10.4149/BLL_2017_054 |
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