Journal info
Aims and Scope |
||
Select Journal
Journals
Bratislava Medical Journal Endocrine Regulations General Physiology and Biophysics 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 Neoplasma Acta Virologica Studia Psychologica Cardiology Letters Psychológia a patopsych. dieťaťa Kovove Materialy-Metallic Materials Slovenská hudbaWebshop Cart
Your Cart is currently empty.
Info: Your browser does not accept cookies. To put products into your cart and purchase them you need to enable cookies.
General Physiology and Biophysics Vol.36, No.3, p.289–296, 2017 |
||
Title: Postsynaptic zinc potentiation elicited by KCl depolarization at hippocampal mossy fiber synapses | ||
Author: Fatima M. C. Bastos, Sandra A. Lopes, Vanessa N. Corceiro, Carlos M. Matias, Jose C. Dionísio, Fernando D. S. Sampaio dos Aidos, Paulo J. Mendes, Rosa M. Santos, Rosa M. Quinta-Ferreira, M. Emilia Quinta-Ferreira | ||
Abstract: The hippocampal mossy fibers contain a substantial quantity of loosely-bound zinc in their glutamatergic presynaptic vesicles, which is released in synaptic transmission processes. Despite the large number of studies about this issue, the zinc changes related to short and long-term forms of potentiation are not totally understood. This work focus on zinc signals associated with chemically-induced mossy fiber synaptic plasticity, in particular on postsynaptic zinc signals evoked by KCl depolarization. The signals were detected using the medium affinity fluorescent zinc indicator Newport Green. The application of large concentrations of KCl, 20 mM and 60 mM, in the extracellular medium evoked zinc potentiations that decreased and remained stable after washout of the first and the second media, respectively. These short and long-lasting enhancements are considered to be due to zinc entry into postsynaptic neurons. We have also observed that following established zinc potentiation, another application of 60 mM KCl only elicited further enhancement when combined with external zinc. These facts support the idea that the KCl-evoked presynaptic depolarization causes higher zinc release leading to zinc influx into the postsynaptic region. |
||
Keywords: Postsynaptic zinc — KCl depolarization — Newport Green (NG) — Mossy fiber synapses — Hippocampal CA3 area | ||
Published online: 01-Jun-2017 | ||
Year: 2017, Volume: 36, Issue: 3 | Page From: 289, Page To: 296 | |
doi:10.4149/gpb_2017001 |
||
|
download file |
|