Acta Virologica Vol.61, No.3, p.341-346, 2017
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Title: Photodynamic Effect of some Phthalocyanines on Enveloped and Naked Viruses |
Author: L. Nikolaeva-Glomb, L. Mukova, N. Nikolova, V. Kussovski, L. Doumanova, V. Mantareva, I. Angelov, D. Wöhrle, A. S. Galabov |
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Abstract: Activity of three photosensitizing phthalocyanine derivatives was tested for photodynamic inactivation towards two coated and two non-enveloped viruses – bovine viral diarrhea virus (BVDV), influenza virus A(H3N2), poliovirus type 1 (PV-1) and human adenovirus type 5 (HAdV5). In the case of coated viruses, a combination of virucidal and irradiation effects was registered by octa-methylpyridyloxy-substituted Ga phthalocyanine (Ga8) toward BVDV, whereas tetra-methylpyridyloxy-substituted Ga phthalocyanine (Ga4) revealed a marked photoinactivation only. No such effect was observed towards influenza A virus. In contrast, the photoinactivating potential of Ga4 and Ga8 marked very high values on naked viruses, especially on HAdV5, at which both the virucidal as well as the irradiation effects became combined.
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Keywords: phthalocyanine; photodynamic inactivation; virus |
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Published online: 28-Aug-2017
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Year: 2017, Volume: 61, Issue: 3 |
Page From: 341, Page To: 346 |
doi:10.4149/av_2017_313
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