Home Bratislava Medical Journal 2018 Bratislava Medical Journal Vol.119, No.2, p.75-80, 2018

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.2

 

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Bratislava Medical Journal Vol.119, No.2, p.75-80, 2018

Title: CdS nanoparticles of different lengths induce differential responses in some of the liver functions of mice
Author: Q. Z. Li, J. Sun, H. T. Shen, S. F. Jia, D. S. Bai, D. Ma

Abstract:

Cadmium sulfide nanoparticles (CdS NPs) are one of important nanoparticle materials which are widely used in photoelectric production, but their potential health hazard to the liver is not clear. This study is aimed at exploring the possible mechanisms of liver injury induced by CdS NPs. Male mice were treated with nanoparticles of 110–130 nm and 80–100 nm cadmium sulfide. The main methods were based on detecting the vigor of superoxide dismutase (SOD) and glutathione (GSH), and content of malondialdehyde (MDA) in both blood and liver tissues as well as on observing the pathological changes in liver tissue. CdS NPs suppressed the activity of SOD and GSH, and increased the serum MDA content (p < 0.05); both effects were observed together in liver tissues of 80–100 nm group (p < 0.05) and were accompanied by an obviously inflammatory response.

CdS NPs induced oxidative damage and inflammatory response in liver tissue, which may be an underlying mechanism for its pulmonary toxicity. Additionally, the toxicity of CdS NPs was closely related to the size of nanoparticles. Pathological results showed that the hepatotoxicity of shorter CdS NPs is greater than that of longer CdS NPs (Tab. 6, Fig. 3, Ref. 20).



Keywords: cadmium sulfide nanoparticles, oxidative damage, inflammation
Published online: 12-Feb-2018
Year: 2018, Volume: 119, Issue: 2 Page From: 75, Page To: 80
doi:10.4149/BLL_2018_014


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