Home Bratislava Medical Journal 2018 Bratislava Medical Journal Vol.119, No.2, p.81-85, 2018

Journal info


 


Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.2

 

Aims and Scope
Editorial Info
Submission Guidelines

Select Journal







Webshop Cart

Your Cart is currently empty.

Info: Your browser does not accept cookies. To put products into your cart and purchase them you need to enable cookies.

Bratislava Medical Journal Vol.119, No.2, p.81-85, 2018

Title: The efficacy of ozone therapy in neonatal rats with hypoxic ischemic brain injury
Author: B. Resitoglu, Y. Celik, M. Komur, A. Polat, S. Erdogan, A. E. Arslankoylu, H. Beydagi

Abstract:

OBJECTIVES: This study is aimed to determine the effect of ozone therapy in neonatal rats with experimentally induced hypoxic ischemic brain injury (HIBI).
METHODS: The study included 7-d-old male Wistar rats that were randomized to the sham, control, ozone 1, and ozone 2 groups. All rats except those in the sham group were kept in a hypoxia chamber, and then the rats in the control group were given 0.5 mL of saline. Those in the ozone 1 group were given ozone 1 mg kg–1 intraperitoneally, and those in the ozone 2 group were given ozone 2 mg kg–1 intraperitoneally.
RESULTS: There were significantly fewer apoptotic neurons in the right hemispheres of the rats in the ozone 1 and ozone 2 groups than in the control group (p < 0.001 and p < 0.001, respectively).

There were significantly fewer apoptotic neurons in the right hemispheres of the rats in the ozone 2 group than in the ozone 1 group (p < 0.001). Morris Water Maze (MWM) test results were similar in the ozone 2 and sham groups.
CONCLUSIONS: The present study’s findings show that ozone therapy reduced neuronal apoptosis and improved cognitive function in neonatal rats with experimentally induced HIBI (Tab. 2, Ref. 30).



Keywords: hypoxic ischemic brain injury, neuroprotection, ozone
Published online: 12-Feb-2018
Year: 2018, Volume: 119, Issue: 2 Page From: 81, Page To: 85
doi:10.4149/BLL_2018_015


download file



© AEPress s.r.o
Copyright notice: For any permission to reproduce, archive or otherwise use the documents in the ELiS, please contact AEP.