Home Bratislava Medical Journal 2018 Bratislava Medical Journal Vol.119, No.2, p.86-91, 2018

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.2

 

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Bratislava Medical Journal Vol.119, No.2, p.86-91, 2018

Title: Neuroprotective effects of high-dose human albumin against traumatic spinal cord injury in rats
Author: T. Yildirim, O. Okutan, E. Akpinar, A. Yilmaz, H. S. Isik

Abstract:

BACKGROUND AND OBJECTIVES: Human serum albumin (HA) is a unique multifunctional protein with neuroprotective properties. We aimed to delineate the mechanisms of HA-induced neuroprotection, supresses inflammatory response and lipid peroxidation after spinal cord injury (SCI).
METHODS AND STUDY DESIGN: Adult female Wistar rats weighing 210–250 g were used for the study. The rats were randomly and blindly allocated into five groups. The one-way analysis of variance (ANOVA) for parametric data and Shapiro–Wilk test was used for evaluating the normal distribution of the variables. Kruskal–Wallis for nonparametric data was used to compare groups. Electron and light microscopies were used to demonstrate ultrastructural changes in spinal cord.
RESULTS: The HA group was significantly different from all the other groups (p < 0.05).

Both MPSS and HA treatments decreased the MPO significantly. HA treatment decreased the lipid peroxidation. HA treatment prevented the worsening of clinical results. In the HA treatment group, the ultrastructure was protected significantly. The neuronal bodies and axonal structures were normal except for some limited edematous spaces.
CONCLUSIONS: HA improves early clinical results, protects spinal cord ultrastructure, and decreases MPO and LPO levels after spinal cord contusion injury (Tab. 3, Fig. 3, Ref. 39).



Keywords: human albumin, spinal cord injury, rats
Published online: 12-Feb-2018
Year: 2018, Volume: 119, Issue: 2 Page From: 86, Page To: 91
doi:10.4149/BLL_2018_016


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