Home Bratislava Medical Journal 2018 Bratislava Medical Journal Vol.119, No.2, p.103-106, 2018

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.2

 

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Bratislava Medical Journal Vol.119, No.2, p.103-106, 2018

Title: Role of autophagy in the progress of coronary total occlusion
Author: G. Demircan, O. Kaplan, S. B. Ozdas

Abstract:

OBJECTIVE: In this study, we measured the level of autophagy enzyme in patients with coronary artery disease (CAD) and investigated whether the role of autophagy existed in the progress of coronary collateral and coronary total occlusion (TO).
METHODS: Overall, 115 participants were included in this study. They were divided into the three groups: group 1: patients had chronic TO (n=49); group 2: patients had acute TO such as myocardial infarction (n=36); and group 3: participants were normal controls (n=30). The enzyme-linked immunosorbent assay (ELISA) kit for autophagy-related protein 5 (ATG5) in the plasma was studied for these three groups.
RESULTS: Autophagy levels were significantly different between the groups (13.7±5.3, 11.7±3.4, and 7.5±3 ng/mL, respectively; p<0.001).

In the subgroup analysis, we found significant positive correlations between the level of autophagy and Rentrop score in the Group 1 (r=0.463, p<0.001).

CONCLUSION: In the present study, autophagy levels were higher in the patients with CAD than in healthy controls. In addition, serum autophagy levels showed a significant positive correlation with the Rentrop score. An increased autophagy level may be considered an important activator and marker of the atherosclerotic inflammatory process in CAD (Tab. 1, Fig. 2, Ref. 20).



Keywords: autophagy, coronary artery disease, coronary artery occlusion
Published online: 12-Feb-2018
Year: 2018, Volume: 119, Issue: 2 Page From: 103, Page To: 103
doi:10.4149/BLL_2018_019


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