Home Bratislava Medical Journal 2018 Bratislava Medical Journal Vol.119, No.2, p.107-111, 2018

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.564

 

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Bratislava Medical Journal Vol.119, No.2, p.107-111, 2018

Title: Effects of complete water fasting and regeneration diet on kidney function, oxidative stress and antioxidants
Author: V. Mojto, A. Gvozdjakova, J. Kucharska, Z. Rausova, O. Vancova, J. Valuch
Abstract: OBJECTIVE: The aim of the study was to observe the influence of 11-days complete water fasting (WF) and regeneration diet (RD) on renal function, body weight, blood pressure and oxidative stress.
BACKGROUND: Therapeutic WF is considered a healing method.
METHODS: Ten volunteers drank only water for 11 days, followed by RD for the next 11 days. Data on body weight, blood pressure, kidney functions, antioxidants, lipid peroxidation, cholesterols, triacylglycerols and selected biochemical parameters were obtained.
RESULTS: WF increased uric acid and creatinine and decreased glomerular filtration rate. After RD, the parameters were comparable to baseline values. Urea was not affected. Lipid peroxidation (TBARS) decreased and maintained stable after RD. Fasting decreased α-tocopherol and increased γ-tocopherol, no significant changes were found after RD. Coenzyme Q10 decreased after RD. HDL-cholesterol decreased in WF. Total- and LDL-cholesterol decreased after RD. Other biochemical parameters were within the range of reference values.
CONCLUSIONS: The effect of the complete fasting on kidney function was manifested by hyperuricemia. Renal function was slightly decreased, however maintained within the reference values. After RD, it returned to baseline values. The positive effect of the complete water fasting was in the reduction of oxidative stress, body weight and blood pressure (Tab. 3, Ref. 25).
Keywords: antioxidants, body weight, complete water fasting, kidney function, oxidative stress, regeneration diet
Published online: 12-Feb-2018
Year: 2018, Volume: 119, Issue: 2 Page From: 107, Page To: 111
doi:10.4149/BLL_2018_020


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