Bratislava Medical Journal Vol.119, No.4, p.210-216, 2018

Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

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Bratislava Medical Journal Vol.119, No.4, p.210-216, 2018
Title: Alternative hypotheses related to Alzheimer’s disease
Author: V. Cubinkova, B. Valachova, I. Uhrinova, V. Brezovakova, T. Smolek, S. Jadhav, N. Zilka

Abstract: Alzheimer’s disease represents the most common form of dementia and belongs to the group of neurodegenerative disorders characterized by progressive loss of neurons in the central nervous system. In the pathogenesis of Alzheimer’s disease several etiologic and pathogenic factors exist, which lead to the dysfunction of neurotransmitter systems and consequent cognitive decline. Last three decades have delivered a crucial progress leading to better understanding of Alzheimer’s disease, however, the exact mechanisms of pathology remain unclear. In this review, we summarize some hypotheses such as amyloid and tau hypotheses, inflammatory processes, prion-like hypothesis, the hypothesis of oxidative stress, vascular and cholesterol hypothesis, the hypothesis of metal accumulation in the brain, cell cycle hypothesis, the hypothesis of impaired insulin signalization and another, which were proposed to explain the pathogenesis of this severe disorder (Ref. 115).

Keywords: Alzheimer´s disease, hypothesis, tau protein, amyloid β
	Published online: 09-Apr-2018
Year: 2018, Volume: 119, Issue: 4	Page From: 210, Page To: 216
doi:10.4149/BLL_2018_039
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