Home Bratislava Medical Journal 2018 Bratislava Medical Journal Vol.119, No.4, p.224-228, 2018

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.2

 

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Bratislava Medical Journal Vol.119, No.4, p.224-228, 2018

Title: Glucagon-like peptide-1 improves mesangial proliferative glomerulonephritis in rats
Author: X. Z. Wang, T. Wu, H. M. Tang, Y. Deng, CH. Li

Abstract:

OBJECTIVE: To investigate the role of GLP-1 in rat with mesangial proliferative glomerulonephritis.
METHODS: A total of 27 normal male Sprague-Dawley rats were randomly divided into 3 groups: NC group (normal control group); MC group (nephritis model rats) and GLP-1 group (nephritis rats treated with GLP-1) with 9 rats in each group. 24-hour urinary protein excretion, serum cystatin C and serum creatinine were tested at the end of 12 weeks. The proliferation of mesangial cells was measured by H&E and TUNEL staining of paraffin sections. The expressions of IKK-β, NF-κB, IL-6 and TNF-α were detected by immunohistochemisty and RT-PCR.
RESULTS: Compared with NC group, 24-hour urinary protein excretion, serum cystatin C and creatinine in MC groups significantly increased (p<0.05, respectively), the 24-hour urinary protein excretion, serum cystatin C and creatinine in GLP-1 group were significantly decreased compared with MC group (p<0.05, respectively).

The relative protein and gene expressions of IKK-β, NF-κB, IL-6 and TNF-α of MC group were significantly up-regulated compared with NC group (p<0.05, respectively). However, compared with MC group, the IKK-β, NF-κB, IL-6 and TNF-α gene and proteins expression were significantly suppressed in GLP-1 group (p<0.05, respectively).
CONCLUSION: The mesangial glomerulonephritis is correlated with GLP-1 and GLP-1 up-regulation had effects to suppress mesangial glomerulonephritis by IKK-β pathway (Fig. 4, Ref. 22).



Keywords: glomerulonephritis, membranoproliferative, GLP-1, IKK-β pathway
Published online: 09-Apr-2018
Year: 2018, Volume: 119, Issue: 4 Page From: 224, Page To: 228
doi:10.4149/BLL_2018_042


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