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Bratislava Medical Journal 2018 Bratislava Medical Journal Vol.119, No.7, p.444–449, 2018
Bratislava Medical Journal 2018 Bratislava Medical Journal Vol.119, No.7, p.444–449, 2018
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Bratislava Medical Journal Vol.119, No.7, p.444–449, 2018 |
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| Title: Endothelin-1 and angiotensin-II modulate urotensin-II vasoconstriction in rat aorta exposed to mercury | ||
| Author: A. H. Ahmed, I. M. Maulood | ||
| Abstract: OBJECTIVES: The aim of this study was to evaluate the possible roles of endothelin-1 and angiotensin-II in urotensin-II vasoconstriction and in endothelial dysfunction induced by mercury. BACKGROUND: Urotensin-II, the most potent vasoactive peptide, is entwined with the cardiovascular diseases and has been labelled as a new pathophysiological biomarker. METHODS: Rat aortic rings were pre-incubated with sb-710411, bq-123, and captopril. Doses of human urotensin-II with increased concentrations were applied in all groups in the presence or absence of mercury chloride. In another set of the experiment, aortic rings were treated with a single dose of mercury chloride in the presence of each of the above blockers. RESULTS: Angiotensin-II and endothelin-1 mediated the vascular responses to the peptide urotensin-II under conditions of both intact endothelium and endothelial impairments induced by mercury. Urotensin-II, angiotensin-II and endothelin-1 significantly participated in vascular responses to mercury chloride. CONCLUSION: The novel finding was that urotensin-II is potentiated under the condition of endothelial dysfunction. Endothelin-1 and angiotensin-II pathways could be heavily exploited in modulating endothelial dysfunction impacts and peptide vascular actions (Tab. 1, Fig. 4, Ref. 30). |
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| Keywords: urotensin-II, endothelial dysfunction, angiotensin-II, endothelin-1, mercury chloride | ||
| Published online: 17-Jul-2018 | ||
| Year: 2018, Volume: 119, Issue: 7 | Page From: 444, Page To: 449 | |
| doi:10.4149/BLL_2018_081 |
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