Home Bratislava Medical Journal 2018 Bratislava Medical Journal Vol.119, No.8, p.490–493, 2018

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.2

 

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Bratislava Medical Journal Vol.119, No.8, p.490–493, 2018

Title: Evaluation of pentraxin-3 in familial Mediterranean fever patients during attack and attack-free periods
Author: M. Gok, O. Sirkeci, M. Kara, Y. S. Sakin, A. Tanoglu, E. E. Sirkeci, H. Oztin, T. Duzenli, M. Kaplan, Y. Yazgan, O. M. Ipcioglu

Abstract: INTRODUCTION: Pentraxin-3 (PTX-3) is a prototype of pentraxin proteins that have been shown to be involved in acute phase response. In this study, we aimed to investigate the relationship between PTX-3 levels and familial Mediterranean fever (FMF) disease, and to evaluate PTX-3 as a novel diagnostic marker of FMF.
METHOD: Forty-three male patients diagnosed with FMF and 42 healthy individuals were included in the study. Patients with other inflammatory diseases and patients who used drugs having anti-inflammatory properties were excluded from the research. Blood samples were obtained during both attack and attack-free periods.
RESULTS: Patient attack periods were confirmed by combining physical examination and elevation of acute phase reactants. Acute phase reactants were significantly higher in attack versus attack-free periods (p < 0.01), however PTX-3 levels were not significantly different between the two periods. Additionally, PTX-3 levels in FMF patients were higher than in controls in both attack (917.29 ± 725.29 vs 451.83 ± 291.95, p < 0.01) and attack-free periods (748.23 ± 487.53 vs 451.83 ± 291.95, p < 0.01).
CONCLUSION: In this study, we showed that PTX-3 levels, in both FMF attack and attack-free periods, were significantly higher than in the control group. Finally, PTX-3 may be a promising biomarker for FMF diagnosis and may predict FMF attacks (Tab. 2, Fig. 2, Ref. 18).

Keywords: familial Mediterranean fever, pentraxin-3, inflammation
Published online: 30-Aug-2018
Year: 2018, Volume: 119, Issue: 8 Page From: 490, Page To: 493
doi:10.4149/BLL_2018_089


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