Home Bratislava Medical Journal 2018 Bratislava Medical Journal Vol.119, No.9, p.535–543, 2018

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.2

 

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Bratislava Medical Journal Vol.119, No.9, p.535–543, 2018

Title: Oxidative stress in Alzheimer disease as a target for therapy
Author: M. Pohanka

Abstract: In the recent time, neurodegenerative disorders like Alzheimer disease were recognized for their significant role in the current healthcare because of their growing incidence and costs for health insurance systems. Effective therapy is missing and even etiology of the diseases like Alzheimer disease is not deeply known. In the case of Alzheimer disease, it is probable that oxidative stress is at least a factor involved in the disease. Nevertheless, the current literature is controversial and ambiguous in this matter. This review is focused on mapping the role of oxidative stress as well as on a consideration that oxidative stress represents the pathway at which a therapeutic strategy can be aimed. This paper provides a survey of contemporary literature on oxidative stress in Alzheimer disease and discusses the opportunities for establishing a therapy based on interfering the stress (Fig. 5, Ref. 117).

Keywords: Alzheimer disease, amyloid plaque, oxidative stress, Fenton reaction, neurodegenerative disorder, reactive oxygen species
Published online: 13-Sep-2018
Year: 2018, Volume: 119, Issue: 9 Page From: 535, Page To: 543
doi:10.4149/BLL_2018_097


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