Home Bratislava Medical Journal 2018 Bratislava Medical Journal Vol.119, No.10, p.613–618, 2018

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.2

 

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Bratislava Medical Journal Vol.119, No.10, p.613–618, 2018

Title: The influence of interferon-γ on cardiac and renal histopathological changes induced by carbamazepine
Author: S. Bahmanpour, F. Karimi, A. Soleimani, M. Kamali, M. R. Namavar

Abstract: BACKGROUND: Carbamazepine (CBZ) is used for the treatment of epileptic seizures. This study was designed to evaluate the effect of Interferon-gamma on the fetal heart and kidney histopathological changes of CBZ-treated pregnant mice.
METHODS: Twenty pregnant mice were divided into four groups. The control group received distilled water. The second group received 240 mg/kg of CBZ by gastric gavage. The third group received intraperitoneal injection (IP) of IFN-γ. The fourth group received IP injection of IFN-γ with 240 mg/kg CBZ by gavage. The fetuses were delivered by hysterectomy on the 18th day of gestation.
RESULTS: The mean weight, crown-rump length, the total volume of the heart and kidney of the fetuses in the CBZ-treated group were significantly reduced when compared with the control, INF-γ and CBZ + INF-γ groups (p < 0.05). INF-γ prevented histopathological changes when used with CBZ (p < 0.05).
CONCLUSION: CBZ induced structural changes in the fetal tissues of the pregnant mice. However, IFN-γ could reduce these changes (Tab. 1, Fig. 4, Ref. 26).

Keywords: carbamazepine, interferon-γ, heart, kidney, mice
Published online: 18-Oct-2018
Year: 2018, Volume: 119, Issue: 10 Page From: 613, Page To: 618
doi:10.4149/BLL_2018_109


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