Home Bratislava Medical Journal 2018 Bratislava Medical Journal Vol.119, No.10, p.619–624, 2018

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.2

 

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Bratislava Medical Journal Vol.119, No.10, p.619–624, 2018

Title: Recombinant adiponectin inhibits inflammation processes via NF-kB pathway in acute pancreatitis
Author: K. Dikmen, H. Bostanci, H. Gobut, A. Yavuz, M. Alper, M. Kerem

Abstract: PURPOSE:  Adiponectin is a protein stemming from adipose tissue and having strong anti-inflammatory properties. We aimed to assess the damage diminishing effects of recombinant adiponectin  (rAD) through NF-kB in the experimental acute pancreatitis  (AP) model.
MATERIALS AND METHODS:  Acute pancreatitis was created by applying 50 µg/kg dose of intraperitoneal cerulean. The rats were randomised and divided into 3 groups as control, AP and rAD groups. Moreover, the rats in each group were divided into two sub-groups as 24th and 48th hour subgroups. rAD was injected in the study group intraperitoneally. Tissue and blood samples were taken after 24 and 48 hours. Histopathological assessment and NF-kB activity were investigated in pancreatic tissue.
RESULTS:  Serum TNF-a, IL-1b and IL-6 levels were found to be statistically significant in the AP group compared to the rAD group in the 24th and 48th hour  (p < 0.05). Similarly, NF-kB activity was also found to be significant in the AP group both in the 24th and 48th hour  (p < 0.05). There were significant differences in the AP and the rAD groups histopathologically in terms of edema, inflammation, vacuolisation and necrosis  (p < 0.001).
CONCLUSION:  rAD has significantly reduced NF-kB activity, cytokine levels and tissue damage  (Tab. 1, Fig. 1, Ref. 51).

Keywords: acute pancreatitis, recombinant adiponectin, cytokines, nuclear factor kappa B
Published online: 18-Oct-2018
Year: 2018, Volume: 119, Issue: 10 Page From: 619, Page To: 624
doi:10.4149/BLL_2018_110


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