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Bratislava Medical Journal 2019 Bratislava Medical Journal Vol.120, No.3, p.200–206, 2019
Bratislava Medical Journal 2019 Bratislava Medical Journal Vol.120, No.3, p.200–206, 2019
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Bratislava Medical Journal Vol.120, No.3, p.200–206, 2019 |
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| Title: Anti-arrhythmic and cardio-protective effects of atorvastatin and a potent pyridoindole derivative on isolated hearts from rats with metabolic syndrome | ||
| Author: B. Liptak, V. Knezl, Z. Gasparova | ||
| Abstract: OBJECTIVES: Aims of this study were to investigate the anti-arrhythmic and cardio-protective effect of atorvastatin and of a new pyridoindole derivative (SMe1EC2) on isolated and perfused hearts while following the Langendorff principles. BACKGROUND: Metabolic syndrome is a widely distributed condition progressing to cardiovascular disease. Many of the metabolic syndrome patients take (HMG)-co-enzyme A (CoA) reductase inhibitors with potential cardio-protective effects. SMe1EC2 is a promising new drug, exerting many positive effects in experimental settings. METHODS: Rats with induced metabolic syndrome were treated with atorvastatin (25 mg/kg) and SMe1EC2 (25 mg/kg and 0.5 mg/kg, respectively) daily for 3 weeks. After the treatment, the hearts were isolated and perfused according to Langendorff. RESULTS: Both atorvastatin and SMe1EC2 improved cardiac function by elevating the left ventricular developed pressure (VLDP) and cardiac contractility. Both SMe1EC2-treated groups improved LVDP during reperfusion, significantly increased ‒dP/dt, and moderately elevated +dP/dt values. The treatment with both atorvastatin and SMe1EC2 (25 mg/kg) significantly reduced malignant arrhythmia in comparison to control group and group treated with SMe1EC2 0.5 mg/kg. CONCLUSIONS: Owing to its anti-arrhythmic and cardio-protective effects, atorvastatin and SMe1EC2 could be of benefit to patients suffering from metabolic syndrome (Tab. 3, Fig. 3, Ref. 41). |
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| Keywords: hyper-triacylglycerolemic rats, Langendorff, ventricular fibrillation, dyslipidemia | ||
| Published online: 19-Mar-2019 | ||
| Year: 2019, Volume: 120, Issue: 3 | Page From: 200, Page To: 206 | |
| doi:10.4149/BLL_2019_034 |
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