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Bratislava Medical Journal 2019 Bratislava Medical Journal Vol.120, No.6, p.429–433, 2019
Bratislava Medical Journal 2019 Bratislava Medical Journal Vol.120, No.6, p.429–433, 2019
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Bratislava Medical Journal Vol.120, No.6, p.429–433, 2019 |
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| Title: The alpha-2 receptor agonist dexmedetomidine attenuates vancomycin‑induced acute kidney injury | ||
| Author: A. Bayram, G. N. Erkan, G. Talih, G. Baskol, K. Deniz, K. Yildiz, A. Esmaoglu | ||
| Abstract: OBJECTIVE: This study was conducted to evaluate the protective effect of dexmedetomidine on nephrotoxicity and the mechanism of renoprotection following vancomycin-induced nephrotoxicity in rats. METHODS: Thirty-two albino Wistar rats were divided into four groups. The control group received intraperitoneal (IP) physiological saline solution, the vancomycin (VMC) group received IP 200 mg/kg vancomycin, the dexmedetomidine (DEX) group received IP 5 µg/kg dexmedetomidine, and the vancomycin and dexmedetomidine (VMC+DEX) group received IP 200 mg/kg vancomycin followed by IP 5 µg/kg dexmedetomidine 20 min after the vancomycin injection. On the 8th day of the experiment, histopathological and biochemical parameters were assessed. RESULTS: Creatinine levels were significantly higher in VMC and VMC+DEX groups. The endothelin-1 level was significantly higher in VMC group. Nitric oxide levels were statistically lower in VMC and VMC+DEX groups. Histopathologic assessments revealed that the extent of renal damage was significantly higher in group VMC (n = 4 with damage of Grade 3) compared to group VMC+DEX (n = 0 with damage of Grade 3). CONCLUSION: It was determined that dexmedetomidine can reduce the extent of renal damage by preventing the elevation of vasoconstrictor agents (Tab. 2, Fig. 1, Ref. 36). |
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| Keywords: dexmedetomidine, nephrotoxicity, rat, vancomycin, vasoconstriction, vasodilation | ||
| Published online: 21-Jun-2019 | ||
| Year: 2019, Volume: 120, Issue: 6 | Page From: 429, Page To: 433 | |
| doi:10.4149/BLL_2019_069 |
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