Home Bratislava Medical Journal 2019 Bratislava Medical Journal Vol.120, No.6, p.429–433, 2019

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.2

 

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Bratislava Medical Journal Vol.120, No.6, p.429–433, 2019

Title: The alpha-2 receptor agonist dexmedetomidine attenuates vancomycin‑induced acute kidney injury
Author: A. Bayram, G. N. Erkan, G. Talih, G. Baskol, K. Deniz, K. Yildiz, A. Esmaoglu

Abstract: OBJECTIVE: This study was conducted to evaluate the protective effect of dexmedetomidine on nephrotoxicity and the mechanism of renoprotection following vancomycin-induced nephrotoxicity in rats.
METHODS: Thirty-two albino Wistar rats were divided into four groups. The control group received intraperitoneal (IP) physiological saline solution, the vancomycin (VMC) group received IP 200 mg/kg vancomycin, the dexmedetomidine (DEX) group received IP 5 µg/kg dexmedetomidine, and the vancomycin and dexmedetomidine (VMC+DEX) group received IP 200 mg/kg vancomycin followed by IP 5 µg/kg dexmedetomidine 20 min after the vancomycin injection. On the 8th day of the experiment, histopathological and biochemical parameters were assessed.
RESULTS: Creatinine levels were significantly higher in VMC and VMC+DEX groups. The endothelin-1 level was significantly higher in VMC group. Nitric oxide levels were statistically lower in VMC and VMC+DEX groups. Histopathologic assessments revealed that the extent of renal damage was significantly higher in group VMC (n = 4 with damage of Grade 3) compared to group VMC+DEX (n = 0 with damage of Grade 3).
CONCLUSION: It was determined that dexmedetomidine can reduce the extent of renal damage by preventing the elevation of vasoconstrictor agents (Tab. 2, Fig. 1, Ref. 36).

Keywords: dexmedetomidine, nephrotoxicity, rat, vancomycin, vasoconstriction, vasodilation
Published online: 21-Jun-2019
Year: 2019, Volume: 120, Issue: 6 Page From: 429, Page To: 433
doi:10.4149/BLL_2019_069


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