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General Physiology and Biophysics 2019 General Physiology and Biophysics Vol.38, No.5, p.435–444, 2019
General Physiology and Biophysics 2019 General Physiology and Biophysics Vol.38, No.5, p.435–444, 2019
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General Physiology and Biophysics Vol.38, No.5, p.435–444, 2019 |
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| Title: The potential developmental programming effect of oral curcumin on the bone health and plasma total osteocalcin of male and female rats fed a high-fructose diet during suckling and post weaning | ||
| Author: Kasimu G. Ibrahim, Hayley L. Wright, Eliton Chivandi, Michael T. Madziva, Kennedy H. Erlwanger | ||
| Abstract: We investigated the effect of oral curcumin on bone health of rats fed a high-fructose diet. Suckling pups (males = 65, females = 63) were gavaged with 0.5% DMSO, curcumin (500 mg/kg), fructose (20%, w/v) or a combination of curcumin and fructose daily from postnatal days 6 to 21. Then the rats were weaned onto normal rat feed for six weeks and each group was sub-divided into two subgroups: one had plain tap water and the other had fructose (20%, w/v) to drink. Blood was assayed for plasma total osteocalcin. Morphometry and radiographic bone density assessments were made on the femora and tibiae. The lengths, masses and Seedor indices of the bones were similar (p > 0.05, ANOVA) across the groups. Males that received curcumin with or without fructose during suckling and weaned onto a high-fructose diet had lower (p ≤ 0.05, ANOVA) osteocalcin concentration versus the other males. Similarly, in female rats, curcumin alone or administered with fructose resulted in lower (p ≤ 0.05, ANOVA) osteocalcin concentration versus female rats administered the vehicle control. Neonatal curcumin-induced decrease in plasma total osteocalcin concentration may predispose to adverse consequences on glucose metabolism and bone health. |
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| Keywords: Bone health, Metabolic syndrome, Childhood obesity, Plasma osteocalcin levels | ||
| Published online: 30-Sep-2019 | ||
| Year: 2019, Volume: 38, Issue: 5 | Page From: 435, Page To: 444 | |
| doi:10.4149/gpb_2019025 |
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