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General Physiology and Biophysics 2019 General Physiology and Biophysics Vol.38, No.6, p.461–471, 2019
General Physiology and Biophysics 2019 General Physiology and Biophysics Vol.38, No.6, p.461–471, 2019
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General Physiology and Biophysics Vol.38, No.6, p.461–471, 2019 |
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| Title: Interaction between LncRNA-ROR and miR-145 contributes to epithelial-mesenchymal transition of ovarian cancer cells | ||
| Author: Jie Li, Songlin Zhang, Lei Wu, Meili Pei | ||
| Abstract: Emerging evidence has indicated that long noncoding RNAs (LncRNAs) play critical roles in tumor development. LncRNA-regulator of reprogramming (ROR) could enhance the malignance of numerous tumors through promoting cell reprogramming and the chemoresistance of several cancers. Nevertheless, the detailed molecular mechanisms of LncRNA-ROR in ovarian cancer are not well elucidated. In our study, we demonstrated that LncRNA-ROR was high expression in ovarian cancer tissues than in normal ovarian tissues, and LncRNA-ROR level was positively associated with clinical stages and the differentiation grades of malignant cells. Functionally, LncRNA-ROR could induce epithelial-mesenchymal transition (EMT), and regulated ovarian cancer cell migration and invasion by decreasing the expression of tumor suppressive miR-145 and its target gene FLNB. Moreover, the binding site for miR-145 within LncRNA-ROR contributed to the reciprocal negative regulation of LncRNA-ROR and miR-145. Taken together, LncRNA-ROR promoted EMT by the miR-145/FLNB regulatory axis in ovarian cancer, providing a potential therapeutic target for ovarian cancer. |
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| Keywords: LncRNA-ROR, miR-145, FLNB, EMT, Ovarian cancer | ||
| Published online: 27-Nov-2019 | ||
| Year: 2019, Volume: 38, Issue: 6 | Page From: 461, Page To: 471 | |
| doi:10.4149/gpb_2019028 |
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