Neoplasma Vol.67, No.2, p.267–276, 2020
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| Title: MiR-1203 is involved in hepatocellular carcinoma metastases and indicates a poor prognosis |
| Author: J. Shi, X. Li, Y. HU, F. Zhang, X. Lv, X. Zhang, Q. Chen, S. Hu |
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Abstract: Non-coding RNAs, especially miRNAs, have been shown to be important regulators in multiple human diseases, including malignant tumors, congenital disease, and autoimmune disease. In this study, we screened the metastasis-associated miRNAs in hepatocellular carcinoma (HCC). Based on the miRNA microarray screening, miR-1203 was confirmed to be the most significant miRNA and was also highly associated with HCC metastases. Bioinformatical prediction indicated direct binding of miR-1203 in SOCS3, which was also confirmed by a dual luciferase reporter assay, resulting in suppression of SOCS3. Increased miR-1203 also promoted invasion of HCC cells through suppressing SOCS3 while no effect on cell proliferation or apoptosis. Circulating expression of miR-1203 and SOCS3 might act as a predictor of metastases and poor prognosis in HCC patients. In conclusion, miR-1203 might promote HCC metastasis by decreasing SOCS3. MiR-1203 predicts a poor outcome in HCC patients and thus might serve as a potential therapeutic target for the prevention of HCC.
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| Keywords: miRNA; metastasis; biomarker; HCC; SOCS3 |
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Published online: 21-Mar-2020
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| Year: 2020, Volume: 67, Issue: 2 |
Page From: 267, Page To: 276 |
doi:10.4149/neo_2019_190414N328
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