Home Bratislava Medical Journal 2020 Bratislava Medical Journal Vol.121, No.1, p.62–66,2020

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

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Bratislava Medical Journal Vol.121, No.1, p.62–66,2020

Title: The negative effect of desflurane on reproductive capacity in female rats
Author: C. Turkler, M. Kulhan, N. G. Kulhan, T. Onat, E. Yildirim, S. Kaplan, H. Suleyman, K. Dinc

Abstract: AIM: The aim of this study was to determine the effect of desflurane on reproductive capacity in female rats through a study of biochemical evaluations.
METHOD: After experimental procedure, the blood samples of female rats were collected, and the malondialdehyde, interleukin‑1‑beta, total glutathione and superoxide dismutase levels were measured to evaluate oxidative stress. In addition to biochemical evaluations, the reproductive performance of the experimental groups was also examined.
RESULTS: The results of our study demonstrated that in blood samples of desflurane‑treated groups of rats, the parameters indicating oxidative stress and inflammation increased, and antioxidant parameters decreased (p < 0.05). It was also proven that repeated desflurane doses caused infertility in female rats, prolonged the gestation period and reduced the number of offspring.
CONCLUSIONS: This study showed that recurrent desflurane application can cause infertility problems through oxidative stress in female rats (Tab. 3, Fig. 1, Ref. 25).

Keywords: desflurane, infertility, oxidative stress, rat, reproductive capacity
Published online: 17-Jan-2020
Year: 2020, Volume: 121, Issue: 1 Page From: 62, Page To: 66

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