Home Bratislava Medical Journal 2020 Bratislava Medical Journal Vol.121, No.1, p.73–78,2020

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

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Bratislava Medical Journal Vol.121, No.1, p.73–78,2020

Title: Differential collagen expression in kidney and heart during hypertension
Author: S. Stanchev, N. Stamenov, V. Kirkov, E. Dzhambazova, D. Nikolov, A. Paloff

Abstract: AIM: The aim of the present study was to investigate the immunohistochemical expression of selected collagen types, namely collagen types I and V and procollagen type III in the renal parenchyma and interstitium and in the myocardium of spontaneously hypertensive rats.
MATERIAL AND METHODS: For the present study, we used two age groups of 6- and 12-month-old spontaneously hypertensive rats. An immunohistochemical analysis was conducted with monoclonal antibodies against collagen types I and V and procollagen type III. A semi-quantitative analysis of immunostaining intensity was conducted with the Image J software.
RESULTS: In the kidney, all three molecules showed higher expression at the age of 12 months, which was particularly notable for procollagen type III and collagen type V, which stained as highly-positive. In the myocardium, the immunoreactivity of collagen types I and V was stronger in 12-month-old animals, while that of procollagen type III did not change substantially.
CONCLUSION: The present study suggests a role of collagen types III and V in hypertensive kidney disease, while also establishing the role of increased expression of collagen types I and V in adverse myocardial remodeling (Tab. 1, Fig. 2, Ref. 48).

Keywords: collagen, kidney, myocardium, hypertension, immunohistochemistry, spontaneously hypertensive rats (SHR)
Published online: 17-Jan-2020
Year: 2020, Volume: 121, Issue: 1 Page From: 73, Page To: 78

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