Home Bratislava Medical Journal 2020 Bratislava Medical Journal Vol.121, No.2, p.107–110,2020

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

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Bratislava Medical Journal Vol.121, No.2, p.107–110,2020

Title: The effect of exercise on reelin level in the hippocampus of diabetic rats
Author: S. Khoshghadam, F. Sheikhzadeh Hesari, N. Ahmadiasl, A. Dastranj Tabrizi, S. S. Hosseinzadeh, A. Ramouz

Abstract: AIM: Diabetes is one of the most common diseases which can attenuate brain function by destroying hippocampus neurons, while reelin is a largely secreted extracellular matrix glycoprotein in the hippocampus causing synaptic plasticity, promoting postsynaptic structures and maturing neurons. The aim of this study was to assess the effect of exercise, as an external factor for neurogenesis in the brain, on reelin levels and memory improvement in diabetic rats.
METHOD: Thirty rats were randomly allocated into three groups; healthy sedentary, diabetic sedentary and diabetic exercise-trained. The experimental group was treadmill-exercised at speed 22 m/min for 1 hour, 5 days per week. Finally, spatial memory of rats was tested and reelin levels were measured.
RESULTS: The results showed that short-term exercise improved spatial memory in diabetic rats but had no effect on reelin levels in the hippocampus of diabetic rats.
CONCLUSION: Diabetes reduced the spatial memory without altering the reelin levels while exercise improved spatial memory without altering the reelin levels (Fig. 4, Ref. 33).

Keywords: reelin, exercise, diabetes, memory, hippocampus
Published online: 22-Jan-2020
Year: 2020, Volume: 121, Issue: 2 Page From: 107, Page To: 110

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