Home Bratislava Medical Journal 2020 Bratislava Medical Journal Vol.121, No.2, p.117–121,2020

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

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Bratislava Medical Journal Vol.121, No.2, p.117–121,2020

Title: Effects of fullerenol nanoparticles on kidney tissue in sevoflurane‑treated rats
Author: V. Sivgin, G. Yalcin, A. Kucuk, S. C. Sezen, N. Afandiyeva, M. Arslan

Abstract: AIM: The aim of this study is to demonstrate whether fullerenol C60 protects renal injury in sevoflurane‑administered rats.
METHOD: Rats (n: 24) were randomly divided into four groups: Control (Group C), Fullerenol C60 (Group F), Sevoflurane (Group S), Fullerenol C60-Sevoflurane (Group FS). Thirty minutes before the procedure, Fullerenol C60, 100 mg/kg, was administered intraperitoneally. Sevoflurane (2.3 %) was applied for 3 hours to rats in S and FS groups. Biochemical and histopathological parameters were analyzed in renal tissue samples. Kruskal–Wallis and Mann–Whitney U tests were used in statistical analyzes.
RESULTS: Malondialdehyde (MDA) level and catalase (CAT) enzyme activity in Group S were significantly higher than that in all other groups. Paraoxanase (PON) enzyme activity in Group S was significantly lower than in Groups C and FS. The histopathological examination showed that vascular vacuolization and hypertrophy (VVH) and lymphocyte infiltration (LI) were significantly higher in the Group S compared to the Group C.
CONCLUSION: Renal histopathology revealed that the administration of Fullerenol C60 prior to sevoflurane inhalation reduced oxidative stress and partially corrected the damage caused by anesthesia. We concluded that Fullerenol C60 has a renal protective effect in rats when administered before sevoflurane anesthesia (Tab. 2, Fig. 4, Ref. 40).

Keywords: fullerenol C60, sevoflurane, renal injury, MDA, PON-1
Published online: 22-Jan-2020
Year: 2020, Volume: 121, Issue: 2 Page From: 117, Page To: 121

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