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Bratislava Medical Journal 2020 Bratislava Medical Journal Vol.121, No.2, p.143–150,2020
Bratislava Medical Journal 2020 Bratislava Medical Journal Vol.121, No.2, p.143–150,2020
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Bratislava Medical Journal Vol.121, No.2, p.143–150,2020 |
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| Title: Exogenous follistatin administration ameliorates cisplatin-induced acute kidney injury through anti-inflammation and anti-apoptosis effects | ||
| Author: E. Koken, E. Oz Oyar, Y. Uyanikgil, B. Azak Pazarlar, C. Bilister, S. Aksun, G. Yigitturk, E. C. Koken | ||
| Abstract: OBJECTIVES: This study was aimed to explore the effects of follistatin on cisplatin-induced renal dysfunction, histopathological changes, apoptosis, inflammation and oxidative damage in rats. BACKGROUND: Follistatin plays an important role in the developmental and regeneration processes of kidney by blocking the actions of activin, which is a member of transforming growth factor-β superfamily. METHODS: Twenty seven rats were separated into 4 equal groups: Control, Cp (cisplatin, 6 mg/kg, intrapertoneally (ip)), F1 (cisplatin + 1 µg/day follistatin ip for 4 consecutive days) and F4 (cisplatin + 4 µg/day follistatin ip single dose) groups. Renal health was monitored by blood urea nitrogen, serum creatinine and histological analysis. Apoptosis, inflammation and oxidative stress was investigated in kidney tissue. Activin A levels in serum and kidney were evaluated as well. RESULTS: Follistatin administration showed a considerable nephroprotective effect against cisplatin-induced nephrotoxicity by preventing renal functional and structural abnormalities, apoptosis and inflammation. The activin A levels in both serum and kidney were also suppressed by follistatin administration. CONCLUSION: Exogenous follistatin ameliorates acute kidney injury, by blocking activin A. The renoprotective effect of follistatin against cisplatin-induced nephrotoxicity appears to be associated with its anti-inflammatory, antiapoptotic and direct nephroprotective actions (Tab. 1, Fig. 7, Ref. 23). |
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| Keywords: activin, acute kidney injury, cisplatin, follistatin, nephroprotection | ||
| Published online: 23-Jan-2020 | ||
| Year: 2020, Volume: 121, Issue: 2 | Page From: 143, Page To: 150 | |
| doi:10.4149/BLL_2020_020 |
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