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General Physiology and Biophysics 2020 General Physiology and Biophysics Vol.39, No.1, p.37–47, 2020
General Physiology and Biophysics 2020 General Physiology and Biophysics Vol.39, No.1, p.37–47, 2020
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General Physiology and Biophysics Vol.39, No.1, p.37–47, 2020 |
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| Title: Common gene haplotypes of gelatinases and their tissue inhibitors in abdominal aortic aneurysm | ||
| Author: Mária Škereňová, Tatiana Matáková, Erika Halašová, Lucia Rišková, Michaela Škorvanová, Dušan Mištuna, Mirko Halaša, Dušan Dobrota | ||
| Abstract: Abdominal aortic aneurysm (AAA) involves complex dynamic remodeling processes in the aortic wall. Gelatinases (MMP2 and MMP9) and their respective tissue inhibitors (TIMP1 and TIMP2) play a crucial role during extracellular matrix (ECM) turnover in aortic tissue. In this study we characterized associations between the haplotypes of genes encoding gelatinase/inhibitor pairs and pathways involved in AAA, a total of 100 AAA patients and 192 controls were enrolled. For males, a significant decrease in the distribution of the minor G allele of the TIMP2 rs8082025 was observed in AAA patients (p = 0.01, 23.1% controls vs. 13.1% AAA). In addition, in males, the major TIMP2 GA haplotype was associated with AAA (86.9% AAA vs. 76.9% control; p = 0.009, OR = 1.997), whereas the TIMP2 GG haplotype (7.7% AAA vs. 13.9% control) was associated with protection against AAA (p = 0.046, OR = 0.518). The minor GAGC MMP9 haplotype was related to AAA for all study subjects as well as the males only subset (p = 0.011, OR = 2.202 and p = 0.025, OR = 2.156, respectively). Small differences in the distribution of gene haplotypes could be associated with different levels of gene expression and in turn influence gelatinases activity in AAA. |
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| Keywords: Abdominal aortic aneurysm, ECM, Gelatinases, MMP, TIMP, Haplotype | ||
| Published online: 01-Feb-2020 | ||
| Year: 2020, Volume: 39, Issue: 1 | Page From: 37, Page To: 47 | |
| doi:10.4149/gpb_2019046 |
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