Home Bratislava Medical Journal 2020 Bratislava Medical Journal Vol.121, No.4, p.259–262,2020

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.2

 

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Bratislava Medical Journal Vol.121, No.4, p.259–262,2020

Title: A new inflammatory marker in overweight patients: triggering receptor expressed on myeloid cells-1
Author: A. Cifci, S. Durmaz Ceylan, K. Oklu , A. Gungunes, D. Katar, I. Karahan, H. Boyunaga, N. Dindar Badem

Abstract: BACKGROUND: Triggering receptor expressed on myeloid cells 1 (TREM-1) is secreted by phagocytes in adipose tissue and it also upregulates the expression of genes involved in the inflammatory response and atherosclerotic conditions. This study was aimed to investigate the serum TREM-1 levels in overweight patients.
METHODS: Twenty-eight subjects in the overweight group (OG) and 20 age-matched healthy subjects in the control group (CG) (BMI 27.6±1.2 vs 23.1±2.17 kg/m2, respectively, p<0.001) were included in the study. The serum sTREM-1 level was measured by ELISA. The homeostasis model assessment score (HOMA-IR) was also calculated.
RESULTS: The mean TREM-1 levels were significantly higher in OG than in CG (407.3±323.7 vs 150.3±152.7 pg/mL, respectively, p<0.001). The HOMA-IR score was also significantly higher in OG than in CG (3.42±3.63 vs 2.77±1.61, respectively). A positive correlation was detected between TREM-1 and BMI (r=0.318, p=0.028).
CONCLUSIONS: This study mainly demonstrated that a high serum TREM-1 level might be an early inflammatory marker in overweight patients. We found that TREM-1 might be associated with BMI in overweight patients regardless of insulin resistance (Tab. 1, Ref. 21). Text in PDF www.elis.sk.


Keywords: TREM-1, insulin resistance, overweight subjects
Published online: 03-Apr-2020
Year: 2020, Volume: 121, Issue: 4 Page From: 259, Page To: 262
doi:10.4149/BLL_2020_039


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