Journal info
|
||
Select Journal
Journals
Bratislava Medical Journal Ekologia - Ecology Endocrine Regulations General Physiology and Biophysics Neoplasma 2025 Ahead of print 2024 2023 2022 2021 2020 2019 2018 2016 2017 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 Acta Virologica Studia Psychologica Cardiology Letters Psychológia a patopsych. dieťaťa Kovove Materialy-Metallic Materials Slovenská hudba 2025Webshop Cart
Your Cart is currently empty.
Info: Your browser does not accept cookies. To put products into your cart and purchase them you need to enable cookies.
Neoplasma Vol.67, No.6, p.1314–1318, 2020 |
||
| Title: Plasma exosomal miR-125a-5p and miR-141-5p as non-invasive biomarkers for prostate cancer | ||
| Author: W. LI, Y. DONG, K. J. WANG, Z. DENG, W. ZHANG, H. F. SHEN | ||
| Abstract: Predictive biomarkers for early diagnosis of prostate cancer are important for its treatment. The functional microRNAs in the exosomes of plasma and serum samples are of interest as stable and non-invasive biomarkers for recurrence in cancer patients. The present study aimed to clarify the value of plasma exosomal mRNA-125a-5p and miR-141-5p miRNAs as biomarkers for the diagnosis of prostate cancer. The study included 19 healthy individuals and 31 prostate cancer patients. In comparison to the levels in healthy controls, exosomal miR-141-5p levels showed a slight increase in prostate cancer patients (P = 0.085), and miR-125a-5p levels that showed a significant decrease in patients with prostate cancer than in healthy controls (P = 0.032). As a derived parameter, the miR-125a-5p/miR-141-5p ratio was significantly higher in patients with prostate cancer than in healthy controls (P ulate that, as diagnostic markers for prostate cancer, miR-125-5p and miR-141-5p might be independent of the PSA. In summary, the results of this study suggest that high plasma exosomal expression of miR-141-3p and low expression of miR-125a-5p in plasma exosomes from prostate cancer patients might be useful markers of specific tumor traits associated with prostate cancer. Moreover, the miR-125a-5p/miR-141-5p ratio seems to perform better than either of the single values alone. |
||
| Keywords: prostate cancer; miR-125a-5p; miR-141-5p; biomarkers | ||
| Published online: 01-Jul-2020 | ||
| Year: 2020, Volume: 67, Issue: 6 | Page From: 1314, Page To: 1318 | |
| doi:10.4149/neo_2020_191130N1234 |
||
|
|
 download file |
|