Acta Virologica Vol.64, No.3, p.297-306, 2020
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Title: MicroRNA-185 reduces the expression of hepatitis B virus surface antigen by targeting PRKCH in HepG2 2.2.15 cells |
Author: R. Zhang, Z. Liu, X. Hou, M. Wang, Y. Xiong, H. Lu, Y. Wang, J. Su, Y. Liu, G. Zhang, Y. Liu |
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Abstract: MicroRNAs (miRNAs) are single-stranded noncoding RNAs with 18 to 25 nucleotides and play critical roles in a wide spectrum of biological processes. We repored that miR-185 inhibited hepatitis B surface antigen (HBsAg) expression and hepatitis B virus (HBV) replication without affecting the proliferation of HepG2 2.2.15 cells, compared with the controls. We identified that protein kinase C eta (PRKCH) is a direct target gene of miR-185 that affects HBV replication and protein expression and that the miR-185 may suppress HBV replication. Our results provide more information for gene therapy in HBV infection.
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Keywords: miR-185; HBV; HBV surface antigen; viral replication; PRKCH |
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Published online: 10-Aug-2020
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Year: 2020, Volume: 64, Issue: 3 |
Page From: 297, Page To: 306 |
doi:10.4149/av_2020_304
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