Home Bratislava Medical Journal 2021 Bratislava Medical Journal Vol.122, No.4, p.280–286,2021

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.2


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Bratislava Medical Journal Vol.122, No.4, p.280–286,2021

Title: Effect of fluid resuscitation on acute lung injury in a rat model of sepsis
Author: A. Erdogan, M. A. Erdogan, A. Y. Kara, S. Bora, G. Yigitturk, O. Erbas

Abstract: AIM: Sepsis is a systemic infection reaction and intravascular volume therapy plays a crucial role in it’s treatment. Acute respiratory distress syndrome (ARDS) occurs in the lungs, the most affected organ. This study aimed to investigate the different effects of fluid therapy on ARDS caused by sepsis.
METHOD: To form a sepsis model, cecal ligation and puncture (CLP) procedure were performed on 44 adult rats. Divided into six groups; normal, CLP group, those treated with 40 ml/kg 0.9 % NaCl, 3 % NaCl (hypertonic saline), Ringer Lactate and Hydroxyethyl starch. After 24 hours treatments, histopathological examination of the lungs were done, and the plasma levels of CRP, TNF-α and IL-6 and paO2 were measured.
RESULTS: The scores of all histological parameters of the group treated with hypertonic saline were significantly lower than of the other groups (p < 0.001). Likewise, according to the arterial blood gas results, paO2 was significantly higher (p < 0.01) in the hypertonic saline group compared to the other groups, and paCO2 was significantly lower (p < 0.01). CRP, TNF-α and IL-6 levels of inflammatory markers were also significantly lower in hypertonic saline groups compared to other groups (p < 0.001).
CONCLUSIONS: Our study shows that treatment with hypertonic saline reduces the progression of ARDS in sepsis (Tab. 3, Fig. 4, Ref. 49).

Keywords: ARDS, inflammation, lung injury, sepsis, volume replacement fluids
Published online: 16-Mar-2021
Year: 2021, Volume: 122, Issue: 4 Page From: 280, Page To: 286

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