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FOR AUTHORS Bratislava Medical Journal 2021 Bratislava Medical Journal Vol.122, No.6, p.386–390,2021
FOR AUTHORS Bratislava Medical Journal 2021 Bratislava Medical Journal Vol.122, No.6, p.386–390,2021
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Bratislava Medical Journal Vol.122, No.6, p.386–390,2021 |
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| Title: Midazolam and dexmedetomidine sedation impair systolic heart function | ||
| Author: N. Omran, V. Skalova, D. Flak, K. Neradova, J. Mandak, P. Habal, R. Skulec, V. Cerny | ||
| Abstract: BACKGROUND: Sedation is an essential part of clinical practice. Despite this fact, we still lack data describing the exact impact of sedation on heart function. PURPOSE: To compare the changes in heart function, induced after sedation with either midazolam or dexmedetomidine, using cardiac magnetic resonance imaging (MRI). METHODS: A total number of 30 volunteers were randomized into two groups: 15 participants in the midazolam group (MID) and 15 participants in the dexmedetomidine group (DEX). Every participant underwent a one-session cardiac MRI before and after sedation onset. The following parameters were recorded: left and right ventricle stroke volume (Ao-vol and Pul-vol resp.) and maximum flow velocity through the mitral valve during early (E-diast) and late diastole (L-diast). A monitor recorded values of mean blood pressure (MAP), pulse (P) and blood oxygen saturation (SpO2) in 5-minute intervals. RESULTS: Dexmedetomidine led to a statistically significant decrease in Ao-vol (p = 0.006) and Pul-vol (p = 0.003), while midazolam decreased E-diast (p = 0.019) Ao-vol (p = 0.001) and Pul-vol (p = 0.01). The late diastolic filling was not influenced by the sedation technique. CONCLUSION: Both sedation regimens worsened the systolic function of both ventricles. Midazolam moreover attenuated early diastolic filling of the left ventricle (Tab. 3, Fig. 4, Ref. 19). |
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| Keywords: cardiac magnetic resonance imaging, cardiac function, midazolam, dexmedetomidine, sedation, critical care | ||
| Published online: 18-May-2021 | ||
| Year: 2021, Volume: 122, Issue: 6 | Page From: 386, Page To: 390 | |
| doi:10.4149/10.4149/BLL_2021_064 |
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