Neoplasma Vol.68, No.6, p.1351–1358, 2021
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Title: A novel intensive conditioning regimen for allogeneic hematopoietic stem cell transplantation in the treatment of relapsed/refractory acute myeloid leukemia |
Author: Yanling Sun, Jingwen Zhang, Bing Long, Xiangzhong Zhang, Ruijuan Wen, Yi He, Xudong Li |
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Abstract: We conducted a prospective study to evaluate the efficacy and safety of cladribine, cytarabine, mitoxantrone, and granulocyte colony-stimulating factor (CLAG-M) regimen combined with busulfan and cyclophosphamide (Bucy) as new intensive conditioning before allogeneic hematopoietic stem cell transplantation (allo-HSCT) in the treatment of relapsed/refractory acute myeloid leukemia (AML). 24 patients were enrolled. The median follow-up was 15.2 months (range 1.9-67.0 months). Except for one patient who died before graft infusion, the evaluable 23 patients (96%) achieved complete remission (CR). The two-year overall survival (OS) rate and leukemia-free survival (LFS) rate were 61.4% and 59.4%, respectively. The non-relapse mortality (NRM) was 9.1%. Univariate analysis revealed that the myeloid blast phase of chronic myelomonocytic leukemia (CMML), an EVI1 mutated, blood blasts ≥ 20% at transplant and extramedullary disease were risk factors for LFS.
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Keywords: relapsed/refractory acute myeloid leukemia; allogeneic hematopoietic stem cell transplantation; intensive conditioning regimen; CLAG-M |
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Published online: 11-Oct-2021
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Year: 2021, Volume: 68, Issue: 6 |
Page From: 1351, Page To: 1358 |
doi:10.4149/neo_2021_210426N573
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