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Bratislava Medical Journal Ahead of print Bratislava Medical Journal Vol.125, No.5, p. 311–317, 2024
Bratislava Medical Journal Ahead of print Bratislava Medical Journal Vol.125, No.5, p. 311–317, 2024
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Bratislava Medical Journal Vol.125, No.5, p. 311–317, 2024 |
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| Title: Expression of BCL2, TP53, FOXA1, and GATA3 in pTa bladder cancer recurrence | ||
| Author: Zuzana VARCHULOVA NOVAKOVA, Stefan HARSANYI, Katarina BEVIZOVA, Marcela KUNIAKOVA, Lucia SCHWARZOVA, Branislav TREBATICKY, Lubos DANISOVIC, Stanislav ZIARAN | ||
| Abstract: OBJECTIVES: In this study, we analyzed pTa bladder cancer (BC) for molecular markers BCL2, TP53, FOXA1, and GATA3 in relation to cancer recurrence. METHODS: We analyzed samples of 79 patients with the pTa stage of BC using a real-time polymerase chain reaction (real-time PCR) between September 2018 and September 2020. The expression levels of BCL2, TP53, FOXA1, and GATA3 were compared with homologous non-tumor bladder tissue. RESULTS: Expression of FOXA1, GATA3, and TP53 was significantly higher (p<0.01) in NMIBC samples compared to homologous non-tumor tissue. The expression of TP53 and FOXA1 in pTa was significantly lower (p<0.01) in the high-grade (HG) tumor when compared to the low-grade (LG) tumor. In contrast, the relative quantification (RQ) of GATA3 was significantly higher (p<0.01) in HG pTa. Patients with recurrence (pTa=33) had significantly higher expression of TP53, and GATA3 (p<0.01), and the gene of FOXA1 (p<0.01) had a significantly lower expression when compared to pTa tumors without recurrence. The expression of Bcl-2 was not statistically significant. CONCLUSION: Our results, indicate, that comparing expression levels of these genes in cancer and cancer-free tissue could provide valuable data, as patients with pTa BC recurrence within up to 54 months of follow-up had a significantly higher RQ of TP53, GATA3, and FOXA1 when compared to pTa BC patients without recurrence (Tab. 2, Fig. 8, Ref. 54). Text in PDF www.elis.sk |
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| Keywords: bladder cancer, gene expression, recurrence, GATA3, FOXA1, TP53, BCL2 | ||
| Published online: 15-Feb-2024 | ||
| Year: 2024, Volume: 125, Issue: 5 | Page From: 311, Page To: 317 | |
| doi:10.4149/BLL_2024_46 |
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